Exonate™ is built on the rapidly evolving field of exosome science - nano-vesicles that deliver powerful biological signals regulating repair, inflammation, and cellular communication.
This page explains how exosomes work, why UCX® (umbilical cord–derived exosomes) are uniquely effective, and how oral delivery supports gut, skin, and systemic wellbeing.
WHAT ARE EXOSOMES?
Tiny Vesicles. Big Influence.
Exosomes are nano-sized vesicles (about 30–150 nanometres) naturally released by almost every cell in the body. You can think of them as messenger packages - tiny envelopes filled with bioactive signals that help cells communicate, adapt, and coordinate repair.
They carry a highly diverse payload of:
proteins
peptides
lipids
micro-RNAs
growth factors
regulatory molecules
Together, these components influence how cells behave, how they respond to stress, and how tissues maintain balance.
Image source:
https://www.researchgate.net/figure/Graphical-representation-of-an-exosome-Exosomes-are-extracellular-vesicles-that-are_fig5_375668744
Exosomes Are the Body’s Internal Communication Network
Instead of forcing change the way pharmaceuticals or supplements do, exosomes guide the body. They tell cells what needs attention, and the body responds.
Current research shows that exosomes play a role in supporting and regulating:
✔ Gut–Immune Signalling
Exosomes help coordinate communication between the gut lining and the immune system.
When this communication is stable, digestion feels smoother, reactions are calmer, and the gut is less “trigger-happy.”
✔ Inflammatory Cascades
Exosomes carry molecules that can tone down overactive inflammatory pathways while supporting the body’s natural repair signals. This balance is especially important for people prone to bloating, gut reactivity, or food-related discomfort.
✔ Epithelial Repair
The gut lining renews every 3–5 days.
Exosomes deliver signals that support epithelial cell turnover, barrier integrity, and healthy mucosal function - all crucial for digestive comfort and nutrient absorption.
✔ Microbiome Crosstalk
Exosomes interact with beneficial gut microbes and can help shape a more stable microbiome environment.
A healthier microbiome means fewer flare-ups, better digestion, and calmer immune responses.
✔ The Gut–Skin Axis
Internal inflammation often appears externally.
Exosomes help regulate the signalling between gut and skin, which is why calming the gut can lead to visibly clearer, more balanced skin.
✔ Cellular Communication & Systemic Balance
Above all, exosomes ensure cells are “speaking the same language.”
This harmonised communication underpins energy regulation, immune balance, and overall wellbeing.
In short:
Exosomes are how the body coordinates repair, regulation, and balance at a cellular level.
They don’t override the body - they teach it how to function better.
WHY ORAL EXOSOMES MATTER
The gut is the body’s master communication hub
The gut is more than a digestive organ - it’s a central signalling centre that influences immunity, inflammation, energy, skin health, mood, and whole-body balance.
This makes the gut an ideal gateway for exosomal bio-signals.
When exosomes are delivered orally in an enteric-coated format, they bypass stomach acid and reach the intestines intact.
Here, they can interact with the exact systems that govern balance throughout the body.
How Oral Exosomes Interact With the Gut
✔ Intestinal Epithelial Cells
The intestinal lining is in constant renewal and is the first line of defence against irritants and pathogens.
Exosomes can support:
- barrier strength (tight junction integrity)
- epithelial repair and turnover
- reduced permeability (“leaky gut” tendencies)
This is one of the foundational reasons many users experience calmer digestion and fewer flare-ups.
✔ The Immune System
Nearly 70% of the immune system sits within the gut.
Oral exosomes can influence immune cells such as macrophages, T-cells, and dendritic cells - helping the immune response shift from reactive to regulated.
This contributes to:
- reduced gut hypersensitivity
- less inflammatory signalling
- improved tolerance to foods and stress triggers
✔ Inflammatory Pathways
Oral exosomes can help down-regulate key inflammatory cytokines that drive discomfort, bloating, and IBS-like tension.
They also promote signals associated with repair and homeostasis. This dual action - calming what’s overactive and supporting what needs repair - makes exosomes uniquely effective in gut-related discomfort.
✔ Microbiome-Mediated Signalling
Exosomes influence microbiome behaviour by:
- supporting beneficial microbial species
- improving microbial diversity
- reducing inflammatory microbial metabolites
- reinforcing cross-talk between microbes and gut lining cells
A more stable microbiome = more stable digestion, skin, and energy.
✔ The Gut–Brain Axis
Inflammation or instability in the gut sends stress signals to the brain.
By supporting calmer gut signalling, exosomes can indirectly promote:
- steadier mood
- calmer nervous system response
- reduced stress-induced gut reactions
This is why many people describe feeling more “regulated” or “grounded” while using Exonate™.
Scientific Support for Oral Exosome Delivery
Although UCX® itself represents a new frontier, oral exosomes are already well-supported through research on milk-derived and plant-derived vesicles.
Across multiple studies, these naturally occurring exosomes have been shown to:
✔ Survive digestion
Milk and plant exosomes remain intact through stomach acid.
✔ Be absorbed in the intestine
They reach intestinal epithelial cells and sometimes even circulate systemically.
✔ Modulate the microbiota
Improving microbial composition and reducing pro-inflammatory patterns.
✔ Repair gut barrier function
Strengthening tight junctions and reducing permeability in colitis models.
✔ Reduce inflammation
Lowering cytokines and supporting a more balanced immune environment.
These findings create a credible and scientifically sound foundation for oral UCX®, especially when delivered in enteric-coated softgels, which protect the bio-signals and ensure they release exactly where they’re needed.
In short:
Oral exosomes matter because the gut is the command centre for inflammation, immunity, energy, and skin health.
Delivering exosomes directly to the intestine allows them to influence epithelial repair, immune balance, microbiome signalling, and the gut–brain axis - creating measurable whole-body benefits from the inside out.
ENTERIC DELIVERY:
HOW EXONATE™ PROTECTS THE BIO-SIGNALS
Why enteric-coated softgels are essential
Exosomes are powerful, but they’re also delicate.
In their natural form, they are vulnerable to the harsh acidic environment of the stomach, where pH levels can break down their lipid membranes and degrade the very signalling molecules that make them effective.
To ensure UCX® exosomes stay intact long enough to reach the part of the body where they can have the greatest impact, Exonate™ uses a specialised enteric-coated softgel - a technology commonly used in advanced pharmaceuticals to protect sensitive compounds.
Why Enteric Coating Matters
✔ Stomach acid rapidly degrades unprotected exosomes
Without protection, most exosomal vesicles would be broken down before they could reach the intestines, eliminating their ability to influence gut–immune signalling, repair pathways, and cellular communication.
✔ Enteric coating dissolves only in the intestines
The coating remains intact in the stomach, shielding the UCX® exosomes from acid.
Once the softgel reaches the higher pH environment of the small intestine, the coating dissolves — releasing the exosomes exactly where they can interact with:
- epithelial cells
- immune tissue
- microbiota
- local inflammatory pathways
This targeted release dramatically increases biological availability.
✔ Protects and preserves biological activity
Enteric delivery helps maintain:
- exosome structure
- signalling cargo integrity
- membrane stability
- functional potency
This allows UCX® exosomes to deliver their full spectrum of reparative and regulatory signals.
✔ Aligns with the body’s natural signalling centres
The gut is home to:
- the majority of immune cells
- the most active epithelial turnover
- dense microbiome communities
- major inflammatory checkpoints
- critical gut–brain communication pathways
Releasing exosomes directly into this environment places them at the command centre of whole-body regulation.
In short:
Enteric coating ensures that UCX® exosomes bypass stomach acid, survive the digestive journey, and are delivered straight into the intestine - the place where they can actually make a difference. With Exonate™, the bio-signals reach the gut intact, active, and ready to support balance from the inside out.
WHY UMBILICAL CORD EXOSOMES (UCX®)?
Not all exosomes are created equal.
Exonate™ uses exosomes derived from human umbilical cord mesenchymal stem cells (hUC-MSCs) for three big reasons:
- Stronger regenerative + immunomodulatory profile
- Lower immunogenicity (less likely to provoke an immune reaction)
- Ethical, non-invasive sourcing with high consistency
1. High Regenerative and Anti-Inflammatory Potential
Umbilical-cord–derived MSC exosomes have demonstrated exceptionally strong regenerative and anti-inflammatory activity across multiple preclinical gut-inflammation models. Research in colitis and IBD-type conditions shows that hUC-MSC exosomes can significantly reduce disease severity by lowering inflammatory cytokines, improving tissue integrity, and supporting mucosal repair.
Studies consistently report benefits such as:
- reduced inflammatory cytokines
- decreased disease activity scores
- improved tissue architecture
- restoration of tight junction proteins
- modulation of immune cell behaviour (including macrophages and T-cell subsets)
These exosomes exhibit a dual capacity to calm inflammatory cascades while promoting epithelial repair, leading some researchers to describe them as having “powerful repair potential” in gut barrier injury models.
While most of these studies use injected exosomes, the mechanisms they demonstrate are clear and relevant. Umbilical-cord exosomes naturally support:
- epithelial repair
- barrier integrity
- immune regulation
- inflammation reduction
These are the exact pathways involved in uncomfortable, reactive digestion - making UCX® particularly suited for promoting a calmer, more stable gut environment.
2. Lower Immunogenicity and Better Compatibility
One of the defining advantages of umbilical-cord exosomes is their naturally low immunogenicity. MSC-derived exosomes in general are known for:
- low risk of immune activation
- absence of tumorigenic potential
- strong biocompatibility
Among MSC sources, umbilical-cord exosomes offer an even better safety and compatibility profile. They are:
- less likely to trigger immune reactions
- highly stable and easy to standardise
- more consistent in their signalling content
- unaffected by age-related or disease-related donor factors
In practical terms:
- They are potent enough to promote repair, and
- quiet enough not to overstimulate the immune system.
For a daily ingestible designed to support regulation rather than stimulation, this low-reactivity profile is a major advantage.
3. Ethical, Non-Invasive, Early-Development Tissue
Umbilical cord tissue - particularly Wharton’s jelly - offers a uniquely ethical and high-quality source of regenerative signalling vesicles. It is:
- collected non-invasively after birth
- tissue that is normally discarded
- rich in youthful, highly active MSCs
- more consistent in biological quality than adult-derived cells
Because adult tissue is influenced by aging, metabolic stress, environmental factors, and disease burden, it can produce exosomes with far more variability.
Umbilical-cord exosomes benefit from:
- a more stable biological profile
- less donor-to-donor variability
- stronger regenerative signalling
- a cleaner ethical footprint
For a premium ingestible intended for global distribution, these sourcing qualities matter greatly.
4. But Can Exosomes Even Work Orally?
Although many umbilical-cord exosome studies use injection routes, research on milk-derived and plant-derived exosomes clearly shows that exosomes can remain active when taken by mouth.
Milk-derived exosomes have been shown to survive digestion, reach the small intestine and colon, interact with gut-lining cells, support barrier integrity, modulate the microbiome, and reduce inflammatory markers in gut-inflammation models.
Plant-derived exosome-like vesicles also stay stable through digestion and have demonstrated the ability to reduce intestinal inflammation, influence immune pathways, reshape microbial activity, and support epithelial repair.
Together, these findings show that orally delivered exosomes can:
- survive the GI tract
- reach and interact with gut cells
- influence immune and inflammatory signalling
- support barrier repair and microbiome balance
These are the same pathways that affect how your digestion feels daily - whether meals feel comfortable or reactive, whether bloating flares up or settles, and whether your gut feels tense or at ease.
In short:
Oral exosomes have repeatedly shown they can survive digestion, reach the gut intact, and positively influence the exact pathways that shape your daily digestive comfort. This is why many people notice calmer digestion, fewer flare-ups, and more predictable gut behaviour when exosome-based oral support becomes part of their routine.
How UCX® Compares to Other Exosome Sources (and Traditional Supplements)
Not all exosomes are the same.
Here’s how UCX® stacks up against other exosome sources - and why it outperforms traditional supplements entirely.
HOW UCX® EXOSOMES SUPPORT THE GUT
The science behind calmer digestion
UCX® exosomes interact directly with the gut’s regulatory systems - the epithelial barrier, immune network, microbiome, and local inflammatory pathways.
Together, these interactions help create a digestive environment that feels calmer, more predictable, and less reactive.
At the physiological level, UCX® exosomes have been shown to influence several key mechanisms that shape everyday gut comfort:
✔ Reinforcing the epithelial barrier
The gut lining acts as both a protective shield and a highly active communication surface.
Exosomes support tight junction integrity and epithelial repair, helping maintain a strong, resilient barrier.
A more stable gut lining reduces the likelihood of bloating, irritation, or “triggered” digestive episodes.
✔ Modulating immune signalling
Because such a large portion of the immune system resides in the gut, overactive immune responses can lead to hypersensitivity, discomfort, or unpredictable flare-ups.
UCX™ exosomes help guide immune cells toward a more regulated, less reactive state - supporting an internal environment that feels steadier and less inflamed.
✔ Regulating inflammatory cytokines
Exosomes can down-regulate pro-inflammatory cytokines while supporting signals associated with repair and recovery.
For the user, this often translates to:
- fewer flare-up days
- less tension in the gut
- more consistent comfort after meals
✔ Reducing gut hypersensitivity
A reactive gut often responds strongly to stress, certain foods, or hormonal shifts.
By calming inflammatory and immune pathways, UCX® exosomes help reduce this hypersensitivity, creating a foundation for smoother digestion and less post-meal discomfort.
✔ Supporting balanced motility
Gut motility - the movement of food through the digestive tract - is highly sensitive to stress and inflammation.
Exosomal signalling helps support healthier motility patterns, which can lead to less bloating, less cramping, and more predictable digestion throughout the day.
✔ Interacting with the microbiome
UCX™ exosomes may support a more stable microbial environment by influencing microbial communication and shaping conditions that favour beneficial species.
A more balanced microbiome is closely tied to better digestion, clearer skin, and overall wellbeing.
How this science shows up in real-life experience
Users often describe outcomes that align directly with these physiological effects:
- less bloating and abdominal tension
- fewer reactive episodes throughout the week
- calmer digestion after meals
- less discomfort from foods that used to trigger symptoms
- more predictable digestion, day after day
- a noticeable reduction in IBS-type sensitivity
These are not just isolated experiences - they are the real-world expression of healthier gut signalling, calmer immune activity, and a stronger, more stable barrier.
In short:
UCX® exosomes help your gut behave more calmly and predictably by strengthening the gut lining, reducing inflammation, regulating immune activity, and supporting a healthier microbiome. The result is digestion that feels smoother, less reactive, and more comfortable - with fewer flare-ups, less bloating, and more stable days.
THE GUT–SKIN AXIS
Why a calmer gut often means clearer, more predictable skin
The skin and gut are deeply connected through what science refers to as the gut–skin axis - a communication pathway linking digestion, immunity, inflammation, and overall skin behaviour. When the gut is reactive or inflamed, it sends stress signals that can influence skin clarity, sensitivity, oil production, and barrier function.
UCX® exosomes influence several of the key mechanisms that shape this relationship:
✔ Lower systemic inflammatory load
When the gut calms, inflammatory signalling across the whole body shifts.
UCX® exosomes help reduce excess cytokine activity in the gut - a major source of systemic inflammation.
Because inflammatory markers circulate, a quieter gut often leads to a quieter, more stable complexion.
Users may notice:
- fewer inflammation-related breakouts
- less redness or reactivity
- a more even baseline in their skin
✔ More stable immune responses
The immune system plays a major role in skin behaviour.
When gut–immune signalling is dysregulated, the skin can become unpredictable or prone to flares.
By helping the gut regulate immune activity, UCX® exosomes support:
- calmer immune communication
- fewer skin flare-ups triggered by internal stress
- a more resilient skin barrier from within
✔ Improved nutrient absorption
Healthy skin depends on nutrient delivery - especially vitamins, minerals, amino acids, and fatty acids.
A reactive gut absorbs nutrients less efficiently, which can show up in skin texture, hydration, and recovery.
By supporting epithelial repair and healthier motility, UCX® exosomes contribute to more effective nutrient uptake, which supports:
- improved skin hydration
- better repair responses
- healthier baseline radiance
✔ Signals that promote healthier epidermal turnover
Exosomes influence how cells communicate - including the pathways that regulate how quickly or efficiently the skin renews.
By calming the internal environment and supporting more balanced inflammatory signalling, UCX® exosomes help promote a clearer, more rejuvenated complexion from the inside out.
This creates visible synergy when used alongside topical exosome therapies.
Exonate™ + ReCellience = Inside–Out + Outside–In Support
Where Exonate™ helps calm the gut and regulate internal signalling, ReCellience products deliver external exosome support directly to the skin.
Together, they address both sides of the gut–skin connection:
- Exonate™ = internal signalling, gut balance, immune regulation
- ReCellience = topical repair, hydration, barrier support
This dual approach creates a more comprehensive renewal pathway - one felt internally and seen externally.
In short:
A calmer gut sends calmer signals to the skin. By reducing internal inflammation, stabilising immune responses, improving nutrient absorption, and supporting cellular communication, UCX® exosomes help the skin behave more predictably - leading to clearer, calmer, more radiant results from the inside out.
SYSTEMIC BENEFITS:
WHOLE-BODY BALANCE
Beyond the gut & skin
While the digestive system is the primary site of exosomal interaction, many users notice benefits that extend well beyond their gut and complexion.
This is because the gut is not just an isolated organ - it is a central signalling hub that influences systemic inflammation, energy regulation, nervous system stability, and cellular recovery.
By helping the gut operate in a calmer, more regulated state, UCX® exosomes contribute to improvements that are felt throughout the body.
✔ More even, sustained energy
When inflammatory load is high or digestion is reactive, the body diverts energy toward regulation and repair.
As UCX® exosomes support inflammatory balance and healthier gut–immune signalling, the body has more energy available for daily function.
Users commonly report:
- steadier energy throughout the day
- fewer mid-afternoon crashes
- a sense of being more “switched on” mentally
These shifts align with improved homeostasis - the body’s ability to maintain internal balance without constant effort.
✔ Reduced inflammation-like body tension
Many people experience tension, heaviness, or general discomfort that isn’t easily explained.
Because systemic inflammation often begins in the gut, reducing inflammatory cytokines at the gut level can have a noticeable effect on how the body feels.
This may look like:
- less background tension
- fewer flare-up days
- reduced “puffy” or inflamed sensations
- more ease in movement and posture
This relates directly to exosomal effects on cytokine regulation and oxidative balance.
✔ Improved recovery and physical resilience
UCX® exosomes support cellular communication pathways involved in repair and regeneration.
When these pathways are clearer and less inflamed, the body recovers from everyday stress more efficiently.
Users may notice:
- quicker recovery after physical activity
- improved tolerance to stressors
- more restorative sleep (due to lowered inflammatory signalling)
- faster return to baseline after busy or demanding days
This reflects the role exosomes play in supporting mitochondrial performance and efficient cellular turnover.
✔ A calmer internal baseline
Gut inflammation can send stress signals throughout the body via the vagus nerve and gut–brain axis.
When the gut becomes more stable, people often describe feeling:
- less reactive
- less wired or overstimulated
- more steady emotionally
- clearer mentally
This is not due to any sedative effect, but to improved regulation within the gut–immune–brain network.
✔ Better resilience to daily stress
When internal signalling is chaotic or overactive, everyday stressors feel more intense.
By promoting improved homeostasis and lowering inflammatory noise, UCX™ exosomes help the body stay grounded under pressure.
This often translates to:
- improved adaptability
- a stronger sense of internal regulation
- smoother emotional responses
- reduced stress-induced digestive symptoms
This effect ties directly into exosomal support for cellular communication and inflammatory modulation.
In short:
By helping the gut regulate inflammation, restore balance, and improve communication across the gut–immune–brain axis, UCX® exosomes support a more stable internal environment. Users often experience steadier energy, less tension, better recovery, and greater resilience to stress - creating whole-body balance that can be felt every day.
SAFETY & PURITY
What Exonate™ does not contain
UCX® exosomes are cell-free, meaning they deliver signalling benefits without carrying any of the components associated with live-cell or stem cell therapies.
Exonate™ contains:
- no cells
- no stem cells
- no DNA
- no biological tissue
- no replication capacity
- no hormones
These vesicles cannot divide, multiply, or behave like stem cells. They are simply purified bio-signalling messengers — similar in nature to exosomes naturally found in human milk and plants.
Purified Through a Multi-Step Process
Each batch undergoes a controlled purification sequence to ensure safety and consistency. This includes:
- filtration to remove cells and larger particles
- isolation steps that concentrate exosomes and exclude impurities
- sterile processing for stability
- testing for purity, size, identity, and microbial safety
The result is a clean, predictable exosomal preparation suitable for daily wellness use.
In short:
Exonate™ contains only purified, cell-free UCX® exosomes - no cells, no DNA, no hormones, and no biological tissue. Through multi-step filtration and advanced purification, each batch is refined to deliver clean, safe, consistent exosomal signals you can trust.
SUMMARY:
THE EXONATE™ DIFFERENCE
Exonate™ is not a probiotic.
Not a vitamin.
Not a herbal extract.
Not a stimulant.
It represents a new scientific category:
Bio-Signal Modulation for Gut + Skin + Whole-Body Regulation
Backed by emerging exosome research, engineered for oral delivery, and powered by UCX® - one of the most potent and consistent exosomal profiles available today.
Ready to Experience the Science Behind UCX® for Yourself?
Exonate™ brings together cutting-edge exosome research, targeted enteric delivery, and the powerful bio-signals of ethically sourced umbilical-cord exosomes - all designed to support a calmer gut, clearer skin, and more balanced days.
If you're ready to experience the difference that deeper cellular communication can make:
Shop Exonate™ Now
Support your gut. Support your skin. Support your whole-body balance.
KEY SCIENTIFIC STUDIES & REFERENCES
⚠️ Important Context & Scientific Honesty
- Most MSC-/umbilical-cord exosome studies use injection rather than oral delivery.
- Oral exosome studies are more common with milk-derived or other natural-source extracellular vesicles.
- The research demonstrates potential mechanisms - not guaranteed outcomes. As with all emerging science, results vary by model (animal vs human), dose, delivery method, and individual physiology.
Given those caveats, these studies nonetheless provide a credible scientific foundation for claims around gut support, barrier integrity, inflammation modulation, and benefit potential for oral exosome use.
MSC / Umbilical Cord Exosomes - Gut Repair, Inflammation & Immune Regulation
1. Tian C. et al. (2023).
Mesenchymal stem cell-derived exosomes: a rationale for novel cell-free therapies for IBD.
Stem Cell Research & Therapy.
→ Demonstrates MSC-exosomes reduce inflammation and support gut repair.
2. Mao F. et al. (2017).
Human umbilical cord mesenchymal stem cell-derived exosomes alleviate inflammatory bowel disease in mice.
Stem Cell Research & Therapy.
→ hUCMSC exosomes reduced colitis severity, cytokines, and tissue damage.
3. Heidari N. et al. (2022).
Regulation of the Th17/Treg balance by hUCMSC-derived exosomes protects against experimental colitis.
Immunology Letters.
→ Shows immune-balancing effects through T-cell regulation.
4. Ocansey DKW et al. (2022).
MSC-derived extracellular vesicles mitigate colitis by regulating gut microbiota and the FXR axis.
Biomaterials Science.
→ Demonstrates microbiome and metabolome modulation with MSC exosomes.
5. Guo G. et al. (2022).
Therapeutic potential of MSC-derived extracellular vesicles in ulcerative colitis and colorectal cancer.
Stem Cell Research & Therapy.
→ Comprehensive review of MSC exosomes in colitis and inflammation.
6. Wang L. et al. (2020).
Exosomes from hUCMSCs reduce inflammation and promote epithelial healing in colitis models.
Journal of Cellular and Molecular Medicine.
→ Confirms epithelial repair and cytokine calming.
Barrier Repair, Tight Junctions & Epithelial Function
7. Yang J. et al. (2015).
MSC-derived exosomes protect intestinal epithelial cells via regulation of tight junction proteins.
American Journal of Physiology-GI.
→ Shows direct tight-junction reinforcement.
8. Chen W. et al. (2019).
Exosomes from MSCs promote mucosal healing and barrier integrity in IBD models.
Journal of Crohn’s & Colitis.
→ Strong evidence of barrier repair and reduced permeability.
Oral Exosomes — Survival Through Digestion & Bioactivity
9. Liao Y. et al. (2017).
Human milk exosomes survive digestion and remain biologically active.
Journal of Nutrition.
→ Direct proof that exosomes survive stomach acid and pancreatic enzymes.
10. Benmoussa A. et al. (2016).
Milk exosomes resist digestion and deliver bioactive miRNAs.
Scientific Reports.
→ Demonstrates vesicle stability and bioactivity post-digestion.
11. Tong L. et al. (2023).
Oral administration of milk-derived extracellular vesicles restores intestinal barrier integrity and attenuates inflammation.
Science Advances.
→ Landmark study showing oral EVs repair barrier + reduce inflammation.
Plant-Derived Exosome-like Nanoparticles (Oral Delivery & Gut Effects)
12. Teng Y. et al. (2018).
Ginger-derived nanoparticles protect against colitis via regulating the gut microbiota and immune system.
Biomaterials.
→ Oral plant exosomes reduce inflammation and modulate immunity.
13. Mu J. et al. (2014).
Plant-derived exosome-like nanoparticles modulate intestinal macrophages and reduce inflammation.
Molecular Therapy.
→ Demonstrates immune-modulating effects via oral delivery.
14. Zhuang X. et al. (2015).
Grapefruit-derived nanoparticles deliver therapeutic agents to the gut via oral administration.
Nature Communications.
→ Proof that exosome-like vesicles orally target gut tissue.
Exosomes & Immune Regulation / Cytokine Modulation
15. Zhang B. et al. (2018).
MSC-derived EVs regulate inflammatory cytokine production and macrophage polarization.
Stem Cell Reports.
→ Supports claims around immune calming & inflammatory balance.
16. Mokarizadeh A. et al. (2012).
MSC exosomes create an anti-inflammatory microenvironment by influencing immune cells.
Immunology Letters.
→ Demonstrates immune de-escalation.
Mitochondrial Support, Cellular Communication & Systemic Balance
17. Phinney DG. et al. (2015).
MSC-derived vesicles transfer mitochondria and support cellular metabolism.
Cell Metabolism.
→ Shows improved mitochondrial function and energy pathways.
18. EL Andaloussi S. et al. (2013).
Extracellular vesicles as regulators of cellular communication.
Nature Reviews Molecular Cell Biology.
→ Broad foundational reference for exosome signalling.
Safety of MSC / Umbilical Cord Exosomes
19. Keshtkar S. et al. (2018).
MSC-derived extracellular vesicles: safe, cell-free therapy with no tumorigenic capacity.
Stem Cell Research & Therapy.
→ Key citation for safety.
20. Mendt M. et al. (2018).
Umbilical cord MSC exosomes show strong therapeutic potential with excellent safety profile.
Oncology Reports.
→ Confirms low immunogenicity and high compatibility.